Marijuana Compound Found Superior To Drugs For Alzheimer’s

By  Sayer Ji

Contributing Writer for  Wake Up World

Could the active ingredient in marijuana, responsible for its characteristic “high,” help turn the tide against the accelerating Alzheimer’s epidemic?

A remarkable study published in the journal  Molecular Pharmacology  in 2006, found that this long vilified plant contains a compound with not one, but  two  therapeutic properties ideal for addressing both the surface symptom (memory problems) and root cause (brain plaque) of Alzheimer’s disease.  [i]    This is an ironic finding, considering that the prevailing stereotype is that using marijuana “fries” the brain, leading to debilitating memory issues.

Researchers discovered that the psychoactive component of marijuana, Δ⁹-tetrahydrocannabinol (THC), both “competitively inhibits the enzyme acetylcholinesterase (AChE) as well as prevents AChE-induced amyloid β-peptide (Aβ) aggregation.”

On the first account, THC’s ability to inhibit the AChE enzyme, is not unlike the mechanism of action behind most Alzheimer’s drugs on the market today. Drugs like  donepezil  (trade name Aricept), for instance, by targeting and inhibiting the brain enzyme acetylcholinesterase (AChE), result in an increase in brain levels of this neurotransmitter, which in turn, results in symptom reduction, i.e. improved memory. Donepezil, however, is riddled with controversy due its well-known  association with seizures, which likely reflects its intrinsic neurotoxicity.   It is, in fact, a chemical in the same general chemical class as venom, insecticides and chemical war agents, such as nerve gas.

On the second account, THC’s ability to prevent the acetylcholinesterase-associated amyloid β-peptide (Aβ) aggregation, i.e. brain plaque, indicates that it may, as the researchers noted, “directly impact Alzheimer’s disease pathology.” In fact, they found “Compared to currently approved drugs prescribed for the treatment of  Alzheimer’s disease, THC is a considerably superior inhibitor of Aβ aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.”

What is so encouraging about this research, and which the researchers described as “noteworthy,” is the following:

THC is a considerably more effective inhibitor of AChE-induced Aβ deposition than the approved drugs for Alzheimer’s disease treatment, donepezil and tacrine, which reduced Aβ aggregation by only 22% and 7%, respectively, at twice the concentration used in our studies.  Therefore, AChE inhibitors such as THC and its analogues may provide an improved therapeutic for Alzheimer’s disease, augmenting acetylcholine levels by preventing neurotransmitter degradation and reducing Aβ aggregation, thereby simultaneously treating both the symptoms and progression of Alzheimer’s disease.

THC, of course, is only one of a wide range of cannabinoids in the plant marijuana. Not only is there already plentiful information on the  neuroprotective properties of marijuana compounds, but there is also a sizeable body of clinical and/or biomedical research indicating the medicinal value of this plant in over 150 health conditions. To view this research visit our  Medical Marijuana Research  page.

Article Sources

[i]  Lisa M Eubanks, Claude J Rogers, Albert E Beuscher, George F Koob, Arthur J Olson, Tobin J Dickerson, Kim D Janda . A molecular link between the active component of marijuana and Alzheimer’s disease pathology.  Mol Pharm. 2006 Nov-Dec;3(6):773-7. PMID:  17140265

Further articles by Sayer Ji:

• Biotech’s Dark Promise: Involuntary  Cannibalism for All
• The Cancer-Causing Metal Millions Eat, Wear or Have Injected Into Their Kids
• Turmeric Superior to Chemical Mouthwash In Improving Oral Health
• Biophotons: The Human Body Emits, Communicates with, and is Made from Light

• The 2013 Measles Outbreak: A Failing Vaccine, Not A Failure To Vaccinate

• 3 Evidence-Based Ways To Reverse Skin Aging Naturally

• Why Is The Food Industry Poisoning Us With Trillions of Nanoparticles?

• How to Clean Your Arteries With One Simple Fruit
• 13 Evidence-Based Medicinal Properties of Coconut Oil

About the author:

Sayer Ji is the founder and director of  www.GreenMedInfo.com  and an advisory board member at the  National Health Federation, an international non-profit, consumer education, health-freedom organization.

He co-authored the book  Cancer Killers: The Cause Is The Cure, and is currently co-authoring another book with Tania Melkonian entitled  EATomology: An Edible Philosophy of Food.

Check out Sayer Ji’s new collaborative project  EATomology.com.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of Wake Up World or its staff.