Groundbreaking Research Links Autism with Histamine, Inflammation and Mast Cell Activation

Groundbreaking Research Links Autism with Histamine Intolerance, Mast Cell Activation

By Carolanne Wright

Contributing writer for Wake Up World

The study of histamine has been attracting quite a bit of attention over the last few years — and not just in relation to seasonal allergies or insect bites. The compound is also associated with a variety of other health complaints, from migraines and depression to schizophrenia. And now scientists have discovered another surprising connection to the naturally occurring chemical: autism.

The Role Histamine Plays in Immune Response

When we come in contact with an allergen that we have a sensitivity to — like pollen or we’re stung by an insect — the body releases histamine to overcome the threat. A series of physiological reactions occur: blood vessels dilate, while mast cells (a type of white blood cell) are activated to attack the invader.

If we experience an angry rash, itchy eyes or swelling, that’s histamine at work. Usually, the reaction subsides quickly once the threat is over. But sometimes, when the body is exposed to an excess of histamine — either through the ingestion of high-histamine foods or with excessive production by the body — an intolerance to the chemical may develop, which can lead to asthma, anxiety, digestive disorders, mood swings, aggression, fatigue and much more. In fact, Dr. Theoharis Theoharides, a mast cell researcher and head of the Molecular Immunopharmacology and Drug Discovery Laboratory at Tufts University, has even found mast cell activation may be the root cause of autism in many children.

The Connection Between Autism and Brain Inflammation

Autism spectrum disorders (ASDs) now affect as many as 1 in 45 children — and the numbers are rising. Considered a neurodevelopment disorder, autism is characterized by varying degrees of dysfunctional communication and social interactions, repetitive and stereotypic behaviors, as well as learning and sensory deficits. [source] Researchers are scrambling to pinpoint the reason for this disturbing trend, but the disorder has proven to be incredibly complex and treatment options are limited.

A promising study published during the summer of 2016 in Translational Psychiatry may shed some much needed light on the root cause of the disorder — and how to address it.

Dr. Theoharides and his colleagues — in collaboration with Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, and the Department of Child Psychiatry at Harvard Medical School — believe they may have uncovered a significant cause of the core symptoms of ASD. Dr. Theoharides is considered an expert in his field and is within the top five percent of most quoted authors in scientific papers.

According to the study:

“Recent epidemiological studies have shown a strong statistical correlation between risk for ASD and either maternal or infantile atopic diseases, such as asthma, eczema, food allergies and food intolerance, all of which involve activation of mast cells (MCs). These unique tissue immune cells are located perivascularly in all tissues, including the thalamus and hypothalamus, which regulate emotions. MC-derived inflammatory and vasoactive mediators increase BBB [blood brain barrier] permeability.”

The findings indicate that levels of pro-inflammatory molecules interleukin (IL-1B, IL-6, IL-17) and tutor necrosis factor (TNF) are elevated in the brain, spinal fluid and blood of autistic patients and increase when the individual is under stress. These molecules are produced directly by mast cells.

Another paper published by Dr. Theoharides in the journal Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease found a similar correlation between mast cell activation and neurodevelopment issues:

“A number of papers, mostly based on parental reporting on their children’s health problems, suggest that ASD children may present with “allergic-like” problems in the absence of elevated serum IgE and chronic urticaria. These findings suggest non-allergic mast cell activation, probably in response to environmental and stress triggers that could contribute to inflammation. In utero inflammation can lead to preterm labor and has itself been strongly associated with adverse neurodevelopmental outcomes. Premature babies have about four times higher risk of developing ASD and are also more vulnerable to infections, while delayed development of their gut–blood–brain barriers makes exposure to potential neurotoxins likely. Perinatal mast cell activation by infectious, stress-related, environmental or allergic triggers can lead to release of pro-inflammatory and neurotoxic molecules, thus contributing to brain inflammation and ASD pathogenesis, at least in a subgroup of ASD patients.”

Likewise, this study study in Cellular and Molecular Neurobiology discovered that “Histamine is one of the few central nervous system neurotransmitters found to cause consistent blood–brain barrier opening” which is a factor in inflammation, cerebral edema and what Dr. Theoharides calls “allergy of the brain” in ASD patients.

Moreover, when large amounts of histamine are present, the body triggers the production of epinephrine (adrenaline) to correct the imbalance. Adrenaline then sparks a flight or fight response within the body. If this heightened state of stress becomes chronic, it interferes with stomach acid production and overall digestion — leading to parasites, pathogenic bacteria and food sensitivities. The body also dumps magnesium and zinc into the muscles to prepare for a quick reaction. This in turn creates deficiencies of these important minerals, which are crucial for the immune system and neurological development. Disruption of sleep, anxiety, learning disabilities and malabsorption issues soon follow.

Reducing Mast Cell Activation

To reduce mast cell activation and subsequent inflammation, several approaches are effective. One is to consume a low-histamine diet. Another is to use carnosine and methylated B vitamins. To breakdown histamine in the digestive tract, supplementing with diamine oxidase (DAO) may be necessary if the individual is susceptible to low DAO levels through genetic heritage or diet. Many times, people who are deficient in DAO also suffer from allergies and auto-immune disorders, both of which are common in ASD individuals.

Dr. Theoharides has also examined the possible use of luteolin and other bioflavonoids such as quercetin for their calming properties in relation to mast cell activation and brain inflammation.

In the paper Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders, Dr. Theoharides concludes:

“Atopic diseases may create a phenotype susceptible to ASD and formulations targeting focal inflammation of the brain could have great promise in the treatment of ASD.”

Related reading:

Article sources:

About the author:

Carolanne WrightCarolanne Wright enthusiastically believes if we want to see change in the world, we need to be the change. As a nutritionist, natural foods chef and wellness coach, Carolanne has encouraged others to embrace a healthy lifestyle of organic living, gratefulness and joyful orientation for over 13 years.

Through her website Thrive-Living.net, she looks forward to connecting with other like-minded people from around the world who share a similar vision. You can also follow Carolanne on Facebook, Twitter and Pinterest.

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  • Anna Van Z

    In light of this information, I wonder how long it will take the medical community to figure out that introducing toxins, heavy metals, and egg components via vaccines, into developmentally vulnerable infants, is not the best plan?

    My guess is that it will continue to be ignored, because Big Pharma.

  • BikeIce

    The obvious question not addressed in this article……is what is triggering this allergic response with mast cell histamine release? Clearly one has to look at the massive amount of chemicals injected into our babies and children via vaccines. Whether it be mercury, aluminum, polysorbate 80 or the vaccine antigen itself, it’s pretty obvious that immature immune systems were never designed to handle this chemical onslaught, therefore it is no surprise autism and many other neurological disorders (ADHD, dyslexia, tics, etc.) are increasing to pandemic levels as a result.

    Histamine release is just one more manifestation of the brain inflammation caused by vaccines. We certainly saw WAY LESS of these disorders 30 years ago when the vaccine schedule was 4 or 5 instead of the insane 69 now before age 14. We even vaccinate pregnant women with the influenza vaccine that has never been proven to work, but does contain mercury! Frankly I consider this to be fetus/child abuse and physicians who push this agenda should be prosecuted as such.

  • bsroon

    Either brilliant minds are thinking alike – or we’re all a little whacked, lol. The vaccines are an obvious and likely cause. i think it would be VERY illuminating to find out how many of these kids with the autism which had mothers with issues – were vaccinated. Most likely all of them.
    It would then be important to find women without the markers and vaccinations – and compare the children’s health.
    The immune system is not working correctly – a strong indication that it’s out of balance because of vaccines interfering with the natural immune processing.

    As another thing to throw into the mix here – many if not all chronic diseases seem to require messengers between cells in order to regulate various aspects of our human health. New findings show that about 30% of these microbial intra – cellular messengers are soil microbiota.

    Which get killed most intensively in factory “conventional” farming. The next most damaging to soil life is tilling – plowing, disking, harrowing, etc. By this standard, the best food systems by far are permaculture and then no-till. Not even true organic, much less much of the corporate “USDA ORGANIC” garbage is nearly as good as these two options for getting those messenger molecules…

  • Susan Mason

    I had a friend who had a very bad reaction during her pregnancy 34 years ago. I remember she got a rash on the back of her calves that was very severe and it was itchy. I am not sure what they treated her with, but a few years later I found out that her child was autistic.