Artificial Sweeteners Found More Weight-Promoting Than Sugar

By Sayer Ji

Contributing Writer for  Wake Up World

A new study published this month (Nov. 2012) in the journal Appetite revealed that when rats* were given the synthetic sweeteners saccharin and aspartame, compared to sucrose (table sugar), they gained more weight even at similar total caloric intake levels.[i]

The researchers set out to experimentally confirm the suggestion that the use of non-nutritive sweeteners can lead to weight gain, noting that “evidence regarding their real effect on body weight and satiety is still inconclusive.”

In the study design, twenty-nine male rats received plain yogurt sweetened with 20% sucrose, 0.3% sodium saccharin or 0.4% aspartame, in addition to chow and water without restriction.   After measuring their cumulative body weight gain, total caloric intake, caloric intake of chow and caloric intake of sweetened yogurt weekly for 12 weeks, they concluded “greater weight gain was promoted by the use of saccharin or aspartame, compared with sucrose, and this weight gain was unrelated to caloric intake. We speculate that a decrease in energy expenditure or increase in fluid retention might be involved.”


Satiety, that is, the ability to satisfy the appetite, should be a function of how nourishing something is. Artificial sweeteners, which divorce sweetness from caloric content (i.e. nourishment), leave the cells without the monosaccharides — primarily glucose — they need and crave, and which is why the sensation of sweetness is hard-wired in our bodies to illicit a feeling of pleasure. Ultimately, nonnutritive synthetic sweeteners could be considered neuroendocrine disruptors, breaking, altering or amplifying the intimately connected feedback loops between pleasure and nourishment, deprivation and fat-storage, exertion and inactivity, some of which are as ancient as life itself.

The fact that the rats in both the artificial sweetener and sugar groups consumed the same amount of calories, highlights how chemicals (aspartame and saccharin), much like pesticides, may actually  poison us into gaining weight. [ii]  [iii]  [iv]

The challenge for millions of consumers around the world is clearly recognizing the dangers of  artificial sweeteners like aspartame, given it is safety approved in 90 nations. Despite reassurances from many world governments, manufacturers and marketers, the research itself does not lend unequivocal support to the view that they are entirely safe.

For those interested in viewing the ‘other side’ of the evidence, you will find peer-reviewed and published research on linking aspartame to over 40 adverse health effects, including fibromyalgia, brain cancer, kidney damage, urinary tract cancer, leukemia and many other serious conditions.[v]  Saccharin has also been linked to urinary tract cancer, DNA damage, aging, atherosclerosis, and hyperinsulinism.[vi]

For healthy alternatives to synthetic sweeteners and sugar, read:  Sweet! Dieting Without the Deprivation.

*While & cites and indexes research performed on animals we do not believe animal experimentation is necessary. For more information read our  dedication page.

Article Sources

[i]  Fernanda de Matos Feijà³, Cà­ntia Reis Ballard, Kelly Carraro Foletto, Bruna Aparecida Melo Batista, Alice Magagnin Neves, Maria Flà¡via Marques Ribeiro, Marcello Casaccia Bertoluci. Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels.  Appetite. 2012 Oct 19. Epub 2012 Oct 19. PMID:  23088901

[ii]  Claudia Twum, Yudan Wei. The association between urinary concentrations of dichlorophenol pesticides and obesity in children.  Rev Environ Health. 2011 ;26(3):215-9. PMID:  22206198

[iii]  Monika Rönn, Lars Lind, Bert van Bavel, Samira Salihovic, Karl Michaà«lsson, P Monica Lind.  Circulating levels of persistent organic pollutants associate in divergent ways to fat mass measured by DXA in humans.  Chemosphere. 2011 Jul 16. Epub 2011 Jul 16. PMID:  21767864

[iv]  Duk-Hee Lee, Michael W Steffes, Andreas Sjödin, Richard S Jones, Larry L Needham, David R Jacobs.  Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes.  PLoS One. 2011;6(1):e15977. Epub 2011 Jan 26. PMID:  21298090

[v],  Adverse Health Effects of Aspartame

[vi],  Adverse Health Effects of Saccharin

About the author:

Sayer Ji is the founder of, a reviewer at the International Journal of Human Nutrition and Functional Medicine, Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, and Steering Committee Member of the Global Non-GMO Foundation.

For more, visit and, or sign up for GreenMedInfo’s free e-Newsletter.

Recommended articles by Sayer Ji: 

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