Research: Roundup Diluted by 450-Fold is Still Toxic to DNA

By Sayer Ji

Contributing Writer for Wake Up World

Research published in the journal Archives of Toxicology indicates that Roundup, the most common formulation of the herbicide glyphosate, is not only more toxic than its constituent ingredients, but is capable of damaging DNA within a human cell line when diluted down to 450-fold lower concentrations than presently used in GMO agricultural applications. In the researchers’ own words, Roundup has “genotoxic effects after short exposure to concentrations that correspond to a 450-fold dilution of spraying used in agriculture.”

The chemical – glyphosate – is the highest selling herbicide in the world and has been identified as having a wide range of potential adverse health effects — largely minimized and/or under-reported — which include over two dozen diseases. Glyphosate’s primary properties of concern are its carcinogenicity, genotoxicity and endocrine disruptive actions. Roundup contains a surfactant known as polyoxyethyleneamine which functions to reduce the surface tension between Roundup and the cells exposed to it, making the cellular membranes more permeable to absorbing glyphosate and other chemicals within the formula. The surfactant in Roundup may therefore be responsible for increasing the toxicity of glyphosate by several orders of magnitude higher than it exhibits by itself.

This new research sheds light on a fundamental problem associated with toxicological risk assessments of agrichemicals (and novel manmade chemicals in general), namely, these assessments do not take into account the reality of synergistic toxicologies, i.e. the amplification of harm associated with multiple chemical exposures occurring simultaneously. Moreover, toxicological risk assessments on novel chemicals are based on the concept of determining “an acceptable level of harm,” instead of protecting those who would be exposed to a chemical by implementing the precautionary principle, i.e. if there is reason to believe that a chemical could cause harm (determined by animal and in vitro studies) then they should be regulated as if they do cause harm to humans. The precautionary principle would require that the manufacturers of these chemicals prove their product is safe to humans before being allowed to release it onto the market or into the environment, rather than putting the burden of proving it unsafe on the consumer and/or exposed populations, as is presently the case.

Glyphosate exposure is now ubiquitous due to the fact that 88,000 tons of it were used in US in 2007 alone, and likely billions of additional pounds globally. Accumulating evidence indicates it is resistant to biodegradation and now contaminates the air, rain and groundwater throughout the areas where it has been applied.

Read More

Roundup Weedkiller: Is This Monsanto’s New ‘Agent Orange’?

Is Monsanto’s Herbicide Harming Male Fertility?

Toxicology Research on Roundup

About the Author

Sayer Ji is the founder and chair of His writings and research has been published in the Wellbeing Journal, the Journal of Gluten Sensitivity, and have been featured on Reuters,,,,, His critically acclaimed essay series The Dark Side of Wheat opens up a new perspective on the universal, human-species specific toxicity of wheat, and is now available for PDF download. Follow Sayer on Facebook or on Twitter


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  • mothman777

    They should publicly cut the hands off people who make this stuff, parade those people round, then execute them by beheading them in public.

    Just feeling a bit Chinese today for some reason. I know what it is, just been watching those Shaolin Temple monks working out on YouTube.

    I don’t like creeps who make money from damaging and killing other people like Monsanto does, especially seeing the maximum that any of those sadistic murdering NWO terrorists could ever be subjected to in real life is some meaningless financial penalty, that in no way reflects the suffering caused to others by the deaths and birth defects that they are responsible for, to further their agenda of world domination with their genocidal GM seeds and genocidal chemicals. Death to Monsanto. Kill them all, kill all their executives; smash their factories, BEFORE THEY KILL US ALL.

  • mothman777

    The following video contains some of the most powerful information on the absolutely lethal effects of GM ‘foods’ on animals and humans that I have ever seen.

    If you are seriously interested in even carrying on living, then you need to see this video; it really is that serious.