Is This Fruit Extract 10,000 Times Better Than Chemotherapy?

By Sayer Ji

Contributing Writer for Wake Up World

Over a quarter of a century ago a study was performed on the seeds of the Soursop fruit, also known as graviola, which at that time demonstrated such amazing cancer-fighting potential, that those exposed to it within the conventional medical community looked upon it with complete incredulity.

Published in the Journal of Natural Products in 1996, Compound 1, one of five extracted from the seed of the graviola fruit, was found to be “selectively cytotoxic to colon adenocarcinoma cells (HT-29) in which it was 10,000 times the potency of adriamycin.”

Adriamycin is the trade name for the chemoagent doxorubucin and is known by the nickname “red devil,” due to both its deep red color and terrible side effects, which include life-threatening, even fatal damage to the cardiovascular system. This abject lack of “selective cytotoxicity” — the ability to kill only the cancer cells and not healthy ones — is what makes Adriamycin so dangerous. And yet, it has been a first line treatment for a wide range of cancers for almost half a century.

Since the 1996 study, little research on graviola was performed. There was a cell study in 1999 which showed it had anti- prostate cancer and breast cancer activity; another 2002 cell study showed that graviola exhibited anti-hepatoma (liver cancer) activity, but nothing as promising as the original 1996 study ever followed.

Then, in 2011, the journal Nutrition and Cancer revealed highly promising research on Graviola and breast cancer. Researchers found that graviola fruit extract (GFE) suppressed so-called oncogene (or cancer-causing gene) expression in the cell and animal models of breast cancer. The oncogene known as epidermal growth factor receptor (EGFR) is commonly over-expressed in breast cancer, and therefore an ideal target for therapy.

According to the researchers

“A a 5-wk dietary treatment of GFE (200 mg/kg diet) significantly reduced the protein expression of EGFR, p-EGFR, and p-ERK in MDA-MB-468 [breast cancer] tumors by 56%, 54%, and 32.5%, respectively. Overall, dietary GFE inhibited tumor growth, as measured by wet weight, by 32% (P < 0.01).” [emphasis added]

The study authors concluded

“These data showed that dietary GFE induced significant growth inhibition of MDA-MB-468 cells in vitro and in vivo through a mechanism involving the EGFR/ERK signaling pathway, suggesting that GFE may have a protective effect for women against EGFR-overexpressing BC [breast cancer].” [emphasis added]

Given these findings the time may be ripe for reconsideration of graviola in the prevention and/or treatment of cancers, such as colon and breast cancer.

About the Author

Sayer Ji is the founder and director of and co-author of the book The Cancer Killers: The Cause Is The Cure with New York Times best-seller Dr. Ben Lerner and Dr. Charles Majors. His writings and research have been published in the Wellbeing Journal, the Journal of Gluten Sensitivity, and have been featured on,,,, and


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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of Wake Up World or its staff.

  • Wayne Donnay

    Research by Dr. Jerry McLaughlin has shown Paw Paw to be stronger than graviola or soursop. They are from the same family and have the same effects on cancer. See “Paw Paw-from discovery to clinical trial” on youtube. I have a few friends that are using it for cancer but it attacks a lot of virus’ as well. He has tested over 3500 plants and found Paw Paw the most effective on cancer. It grows in the central US. The twigs are the most potent portion of the plant rather than the fruit. Please check it out, you’ll be glad you did. Thank you Dr. Jerry McLaughlin

  • janice areora

    So what part do you have to eat… the seeds of Soursop and the branches of the Paw Paw plant? I would like more info. Thanks!

    • Wake Up World

      Hi Janice,

      For more information, I’d recommend you visit the website .. which is hosted by the acticle’s author Sayer Ji.

      You can contact him via this link .. or by selecting the ”Contact Support” option on his home page.

      Warm regards,
      Andy @ WuW

  • Chris

    I got this warning on another site concerning Graviola, so be careful…
    Paw Paw or Graviola should NOT be used with ANY OTHER alternative cancer treatment!!! NONE!!!

  • Wayne Donnay

    Dr. Jerry Maclaughlin has written about these compounds in many papers (over 300 total!) that he published, most of them published in prestigious publications such as the Journal of Natural Products, Heterocycles, Journal of the American Chemistry Society, Phytotherapy Research, Journal of Organic Chemistry, Journal of Medicinal Chemistry, and others. Several of these papers note the chemical differences between the acetogenins found in the two species, and discuss what makes those in paw paw much more powerful.

    He says it helps to keep the body from becoming resistant to Chemo drugs. I know someone using it with Chemo. Good luck everyone!