How Coconut Oil May Rescue The Brain From Alzheimer’s Disease

coconut_oil_benefits

By Sayer Ji

Contributing Writer for Wake Up World

The Internet loves a good “natural cure” recovery story. For instance, when Dr. Mary Newport, MD, dramatically reverses her husband’s symptoms of Alzheimer’s disease after just two weeks of adding coconut oil to his diet, thousands enthusiastically share the story. But despite their popularity, anecdotes rarely stand the test of time, nor the scrutiny of the medical community, at least not like experimental research published in peer-reviewed biomedical journals.

All the more reason to celebrate a promising study published in the Journal of Alzheimer’s Disease titled, “Coconut Oil Attenuates the Effects of Amyloid-β on Cortical Neurons In Vitro.”[i] The study lends fresh experimental support to an accumulating body of anecdotal reports that coconut oil may alleviate and/or regress cognitive deficits associated with aging and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s.

Medical researchers from the Memorial University of Newfoundland, St. John’s, NL, Canada, undertook a pilot study to investigate the effects of coconut oil supplementation directly on cortical neurons treated with amyloid-β (Aβ) peptide in vitro. Aβ peptide is the main component of certain deposits found in the brains of patients with Alzheimer’s disease believed to contribute to the disease.

The researchers noted that a clinical trial, which we reported on in our article MCT Fats Found in Coconut Oil Boost Brain Function in Only One Dose, reported significant improvements in Alzheimer’s disease patients after 45 and 90 days of treatment with medium chain triglycerides from coconut oil. They pointed out that this trial led to the marketing of the FDA-approved ‘medical food’ caprylidene (trade name Axona), but that the public has shown greater interest in coconut oil itself as a potential therapy, owing to its far greater affordability and availability.

The researchers sought to test the hypothesis that coconut oil is beneficial for neurodegenerative conditions using a cell model. Live rat neurons were exposed to various combinations of Aβ peptide and coconut oil, with the result that Aβ peptide reduced survival of neurons and coconut protected against this Aβ-induced reduction in survival time. The researchers noted that coconut treated Aβ cultured neurons appeared “healthier,” and that coconut oil “rescued” Aβ-treated neurons from mitochondrial damage caused by their toxicity. The researchers observed coconut oil preventing Aβ-induced changes in mitochondrial size and circularity. These findings have great significance, as mitochondria function is often compromised in the brains of Alzheimer’s disease patients.

According to the researchers, “The rationale for using coconut oil as a potential AD [Alzheimer’s Disease] therapy is related to the possibility that it could be metabolized to ketone bodies that would provide an alternative energy source for neurons, and thus compensate for mitochondrial dysfunction.” The researchers proposed that ketone bodies formed as a byproduct of coconut oil metabolism may offset Aβ-induced impairment of mitochondrial function and thus energy metabolism. Considering that the medium chain triglyceride found in coconut known as caprylic acid does cross the blood-brain barrier, and has been found to have anti-convulsant, in addition to, ketogenic effects, coconut oil likely does have a neuroprotective effect.[ii]

The researchers concluded, “The results of this pilot study provide a basis for further investigation of the effects of coconut oil, or its constituents, on neuronal survival focusing on mechanisms that may be involved.”

Clearly, one of the ways that coconut oil can ‘rescue’ the brains of Alzheimer’s patients is by addressing the metabolic derangement in the brain associated with the condition, or what is known as “type 3 diabetes.” As the brain ages, it becomes increasingly resistant to insulin, and therefore incapable of using glucose efficiently to meet its significant energy needs — hence the metaphor “type 3 diabetes.” Thankfully, nature has devised an alternative fuel source for the brain that is independent of glucose utilization and the insulin signaling system, namely, the use of ketone bodies. Coconut oil provides the substrate for the immediate production of these ketone bodies, enabling significant quantities to be produced within a matter of only minutes following ingestion. This metabolic restoration of function may explain why remarkable recoveries in cognitive function and memory have been observed, anecdotally.

Putting the science aside for a moment, coconut, like walnuts, both obey the so-called ‘doctrine of signatures.’ Both foods are encased by a skull-like shell, and contain within a fatty acid-rich ‘meat,’ that feed the organ – the brain – they resemble. Could the poetry of our direct experience tell us something about the value this food has to our brain, or should we continue to play agnostic and exercise great caution incorporating a ‘food as medicine’ approach until the men in white coats, and powerful economic forces behind them willing to shell out millions, if not billions of dollars, to “prove” in randomized, double-blind, placebo-controlled fashion something we probably already know is true?

For additional research on the benefits of coconut oil visit our research page on the topic: coconut oil health benefits. Or, visit our neurodegenerative diseases page for dozens of natural substances studied that may help these conditions.

Updated September 2014

Article Resources

[i] Firoozeh Nafar, Karen M Mearow. Coconut Oil Attenuates the Effects of Amyloid-β on Cortical Neurons In Vitro.

[ii] Wlaz P, Socala K, Nieoczym D, Luszczki JJ, Zarnowska 296 I, Zarnowski T, Czuczwar SJ, Gasior M (2012) Anticon- 297 vulsant profile of caprylic acid, a main constituent of the 298 medium-chain triglyceride (MCT) ketogenic diet, in mice. 299 Neuropharmacology 62, 1882-1889.

Further articles by Sayer Ji:

About the author:

Sayer-JiSayer Ji is the founder and director of www.GreenMedInfo.com and an advisory board member at the National Health Federation, an international non-profit, consumer education, health-freedom organization.

He co-authored the book Cancer Killers: The Cause Is The Cure, and is currently co-authoring another book with Tania Melkonian entitled EATomology: An Edible Philosophy of Food.

Check out Sayer Ji’s new collaborative project EATomology.com.


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