Grape Seed Extract Superior To Blockbuster Diabetes Drug, Preclinical Study Finds

grape seed extract diabetes

By  Sayer Ji

Contributing Writer for Wake Up World

A study published in the  Journal of Cell Communication and Signaling  compared the effects of a grape seed extract (GSP) to the diabetes drug metformin (MET) in rats fed a high fat, high  fructose diet  (HFFD) designed to provoke  insulin resistance.

In the study titled “Grape  seed  proanthocyanidins and  metformin  act by different mechanisms to promote insulin signaling in rats fed high calorie diet”, Indian researchers discovered that both substances reduced elevated blood glucose (hyperglycemia) and elevated blood insulin (hyperinsulinemia), while improving the following diet-altered parameters: glycolysis, tyrosine phosphorylation of IR-β and IRS-1, IRS-1-PI3K association and Akt activation.[1]

Furthermore, adverse changes induced in the rats by the HFFD, such as the activation of tumor necrosis factor-α, interleukin-6, leptin and suppression of cytokine signaling-3 and reduction in adiponectin,  were reversed by Grape  Seed  Proanthocyanidins  more effectively than by Metformin.

Proanthocyanidins are a type  of  secondary plant metabolites known as flavonoids found in  many  plants, but are particularly concentrated in cocoa beans, cinnamon, grape seeds and skin, and maritime pine bark (pycnogenol). Proanthrocyanidins are known primarily through their antioxidant properties, but a  research project has identified at least 20 beneficial physiological actions to this phytochemical class relevant to at least 50 disease states.[2]

Metformin, on the other hand, is an oral  antidiabetic drug  in the  biguanide  class, and is used as the  first-line drug for the treatment of  type 2 diabetes. The original inspiration for the biguanide class was the discovery, in the 1920s, of guanidine compounds within the herb French lilac (Galega officinalis), long used to treat diabetes in traditional medicine. Metformin, however, is an entirely synthetic compound, whose exact mechanisms of action are unknown. What is known is that like other antidiabetic drugs (e.g. Avandia) metformin is cardiotoxic and has been linked to increased cardiac mortality in a number of studies.[3]  Proanthrocyanidins, and grape seed extract in particular, have been extensively researched to have protective and therapeutic properties on the cardiovascular system.[4]

Clearly, the weight of evidence suggests that grape seed proanthrocyanins hold great promise as a  metformin alternative  and/or  anti-diabetic agent. Unfortunately,  the law forbids the medicinal use of natural substances, and lacking the $800 million plus required on average to fund the clinical trials necessary to file for FDA drug approval, health consumers are left almost entirely without guidance from conventional medical practitioners who lose their FDA-underwritten liability shield when they deviate from the drug-based standard of care.

Of course, the deeper level of self-care focuses on identifying the environmental, dietary and lifestyle-based causes of blood sugar and insulin disorders, and altering them so that a magical “pharmaceutical” or “nutraceutical” bullet isn’t necessary. For more research on the many problem substances, natural substances, therapeutic actions and lifestyle interventions that may prevent and/or reverse blood sugar disorders, visit GreenMedInfo’s health guide on the topic:  Health Guide:  Blood Sugar  Problems.


[1]  Baskaran Yogalakshmi, Saravanan Bhuvaneswari, S Sreeja, Carani Venkatraman Anuradha.  Grape seed proanthocyanidins and metformin act by different mechanisms to promote insulin signaling in rats fed high calorie diet.  J Cell Commun Signal. 2013 Sep 12. Epub 2013 Sep 12. PMID:  24026800

[2] Research > Keywords >  Proanthrocyanidins

[3] Research > Problem Substances >  Metformin

[4] Research > Substances >  Grape Seed Extract

Further articles by Sayer Ji:

About the author:

Sayer-JiSayer Ji is the founder and director of  and an advisory board member at the  National Health Federation, an international non-profit, consumer education, health-freedom organization.

He co-authored the book  Cancer Killers: The Cause Is The Cure, and is currently co-authoring another book with Tania Melkonian entitled  EATomology: An Edible Philosophy of Food.

Check out Sayer Ji’s new collaborative project

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