Depression and Contraceptive Pills: A Deep Dive into the Startling Research Findings

July 6th, 2023

By John Patterson

Staff Writer for Wake Up World

In today’s fast-paced world, depression has emerged as a leading cause of ill health and disability, affecting millions of people worldwide. Surprisingly, a recent study has shed new light on a potential factor contributing to this global issue – the use of contraceptive pills.

While the influence of these pills on mental health has long been a topic of discussion, the results have often been inconclusive. However, a ground breaking study, one of the largest to date, has examined the lives of over a quarter of a million women from birth to menopause, providing crucial insights into the relationship between contraceptive pills and depression.

Teenagers at Greater Risk

The study, conducted by researchers from Uppsala University, focused on combined contraceptive pills containing progestogen and estrogen. The findings revealed a startling trend: women who began using contraceptive pills as teenagers experienced a 130 percent higher incidence of depressive symptoms. Among adult users, the increase was still significant, reaching 92 percent. Therese Johansson, a leading researcher in the study, explains that the profound hormonal changes experienced during puberty may amplify the impact of contraceptive pills on teenagers’ mental well-being. The study suggests that teenage users, who have already undergone substantial hormonal changes, may be more susceptible to both hormonal fluctuations and other life experiences.

Long-Term Effects

Interestingly, the study also explored the long-term effects of contraceptive pill use. It was observed that the increased incidence of depression declined when women continued to use contraceptive pills after the initial two years. However, teenage users of contraceptive pills still exhibited a higher risk of depression even after discontinuing the pill, a phenomenon not observed among adult users. These findings emphasize the need for healthcare professionals to be vigilant and consider the interplay between different bodily systems, such as depression and contraceptive pill use.

Balancing the Benefits

Despite the potential risks, the study underscores the numerous advantages of contraception for women’s health. Johansson emphasizes that “combined contraceptive pills are an excellent option for many women” as they offer protection against unplanned pregnancies and help prevent illnesses such as ovarian and uterine cancer.

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It is crucial for medical practitioners and patients alike to be aware of the potential side effects identified in this and previous research. By informing women considering contraceptive pill use about the possible risk of depression, care providers can facilitate well-informed decisions about their contraceptive options.

Further Research

While this study focused exclusively on combined contraceptive pills, the researchers acknowledge the need to explore other contraceptive methods as well. Johansson states, “In future studies, we plan to examine different formulations and methods of administration.” By comparing various contraceptive options such as mini pills, patches, hormonal spirals, vaginal rings, and contraceptive rods, researchers aim to provide women with even more comprehensive information to aid in their decision-making process.


As the prevalence of depression continues to rise, it is essential to explore potential contributing factors comprehensively. The recent study’s findings provide valuable insights into the association between contraceptive pills and depression, particularly among teenage users. While the majority of women tolerate external hormones well, it is crucial to recognize that some individuals may be at an increased risk of depression after starting contraceptive pill use. By fostering awareness and promoting open conversations, healthcare professionals can empower women to make informed decisions about their contraceptive choices, ultimately prioritizing both their reproductive health and mental well-being.


  1. T. Johansson, S. Vinther Larsen, M. Bui, W. E. Ek, T. Karlsson, Å. Johansson. Population-based cohort study of oral contraceptive use and risk of depressionEpidemiology and Psychiatric Sciences, 2023; 32 DOI: 10.1017/S2045796023000525

About the author:

John Patterson is an avid writer and researcher who delves into the latest scientific research. With an insatiable curiosity, he translates complex concepts into accessible narratives, allowing readers to embark on a journey of discovery. Through his work, John bridges the gap between experts and the public, igniting curiosity and inspiring meaningful conversations about scientific breakthroughs.

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